Adenophostin A hexasodium Salt

Adenophostin A, Hexasodium Salt is one of the most potent known agonist of IP3R-I (type 1 inositol 1,4,5-trisphosphate receptor, InsP3R; EC|50|= 10.9 nM). Shown to exhibit about 50- to 100-fold greater affinity for IP3R than IP3. Adenophostin A, Hexasodium Salt has shown to stimulate Ca|2+|release from Ins(1,4,5)P3-sensitive Ca|2+|stores in microsomal preparations, permeabilized cells, and lipid vesicles containing purified InsP3R (EC|50|= 14.7 nM for Ca|2+|release from permeabilized hepatocytes). Adenophostin A, Hexasodium Salt does not bind to Ins(1,3,4,5)P4 binding sites and is resistant to enzymatic degradation.Adenophostin A hexasodium Saltis a potent IP3 receptor agonist. Specification: ≥90% Molecular Formula: C16H20N5O18P3•6Na Molecular Weight: 801.2 PubChem CID: 16760243 Isomeric SMILES: C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H](C([C@H](O3)CO)OC4C(C(C(C(O4)CO)OP(=O)([O-])[O-])OP(=O)([O-])[O-])O)OP(=O)([O-])[O-])N.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A388750-SCI_c32cff57003975c435db3a4a2ecae532.pdf