General description
Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
Specificity
Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins.
Immunogen
Synthetic peptide from Sox10.
Application
Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Neuronal & Glial Markers
Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used.
Optimal working dilutions must be determined by the end user.
Target description
Approx. 55 kDa
Linkage
Replaces: AB5774
Physical form
Affinity purified immunoglobulin. Liquid.
Storage and Stability
Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
biological source: rabbit. Quality Level: 100. antibody form: affinity purified immunoglobulin. clone: polyclonal. purified by: affinity chromatography. species reactivity: mouse. manufacturer/tradename: Chemicon®. . technique(s): western blot: suitable. NCBI accession no.: NM_006941.3. UniProt accession no.: P56693. shipped in: wet ice. target post-translational modification: unmodified. Storage Class Code: 10 - Combustible liquids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51202414
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- AB5727
