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bi-3663 (c09-1113-610)

BI-3663 (C09-1113-610)

Aladdin

Catalog No.
C09-1113-610
Manufacturer No.
B650789-1mg
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA
Price: $661.08
List Price: $734.53

BI-3663 is a highly selective PTK2 / FAK PROTAC ( DC 50 =30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC 50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 ( HY-124625 ) linked to

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BI-3663 is a highly selective PTK2 / FAK PROTAC ( DC 50 =30 nM), with Cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC 50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 ( HY-124625 ) linked to Pomalidomide ( HY-10984 ) with a linker Anti-cancer activityIn VitroBI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC 50 s of 7.6 and 7.9, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:PTK2/FAK 18 nM (IC 50 ) Cereblon. Specification: 0.99 Molecular Formula: C44H42F3N7O12 Molecular Weight: 917.84 PubChem CID: 137628657 Isomeric SMILES: COC1=C(C=CC(=C1)C(=O)NCCOCCOCCOCCC(=O)NC2=CC=CC3=C2C(=O)N(C3=O)C4CCC(=O)NC4=O)NC5=NC=C(C(=N5)OC6=CC=CC7=C6C(=O)CC7)C(F)(F)F
UPC:
12352209
Condition:
New
Availability:
8-12 weeks
Weight:
1.06 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
B650789-1mg
CAS:
2341740-84-7
Product Size:
1mg


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