Calcium Signaling Agents

Brominated analog of the widely used cation ionophore A23187 (Cat. No.

Application 4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca 2+ /calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1)

A cell-permeable PKC activator (K i = 11.9 nM for PKC&#945) that efficiently enhances non-amyloidogenic &#945-processing of amyloid precursor protein (APP) but lacks any tumor promoting activity.

A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 &#181M in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No.

Specificity Recognizes Calcium Sensing Receptor (CaSR). Immunogen A 20 amino acid peptide sequence near the C-terminus of human CaSR.

Specificity Recognizes Cav3.1.

Packaging Packaged under inert gas Warning Toxicity: Regulatory Review (Z) Legal Information CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

A thiazolidinedione that is designed to target the ATX active site thr210 with a boronic moiety and shown to potently inhibit ATX lysoPLD activity (IC 50 ~28 nM using recombinant human ATX or human plasma) in a reversible manner with a mixed-type

An orally bioavailable piperazinylbenzoxazolone compound that acts as a substrate competitive and tight-binding inhibitor of autotaxin activity {IC 50 = 2.8 and 1.

A ~5-fold more potent (IC 50 = 5.7 nM) para -isomer boronate analog of Autotaxin Inhibitor II, HA130 (Cat.

A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/&#946-catenin (&#880580% inhibition at 15 &#181M in &#946-catenin/Tcf-dependent cellular reporter assays) and PPAR&#947/&#948 (&#880530% inhibition at

A potent, specific, and orally active C5a receptor antagonist. Shown to inhibit the binding of 125 I-rhC5a to human neutrophils with a K i of 2.