Bufuralol hydrochloride (C09-1113-530)

Bufuralol (Ro 3-4787) hydrochloride is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrateIn VitroBufuralol (Ro 3-4787) hydrochloride is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoBufuralol (Ro 3-4787) hydrochloride metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:β adrenergic receptor. Molecular Formula: C16H24ClNO2 Molecular Weight: 297.82 PubChem CID: 151573 Isomeric SMILES: CCC1=CC=CC2=C1OC(=C2)C(CNC(C)(C)C)O.Cl