Apoptosis Inhibitors

Mouse monoclonal antibody supplied as undiluted ascites. Recognizes the &#946 6 integrin chain.

A cell-permeable benzoquinone compound that exhibits antitumor properties. Specifically antagonizes XIAP (X-linked inhibitor of apoptosis)-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3

A cell-permeable retinoid-related molecule that induces tumor growth arrest and apoptosis. The exact molecular basis of the underlying mechanism(s) is not yet well understood, however, studies using ovarian adenocarcinoma cells have shown that

Actinomycin D: Classical anti-neoplastic drug. Cytotoxic inducer of apoptosis against tumor cells.

A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 &#181M completely blocks

A cell permeable diaminopyrimidine derived compound that acts as a highly potent and selective inhibitor of Aurora A (IC 50 = 48 nM). Acts by binding to the hinge region via a pyrazole moiety and stabilizes a DFG-in, inactive conformation of Aurora

Cell Line Origin Mouse NS0 x Mouse BALB/c spleen Cell Line Description The antibody recognises the human leukocyte common antigen CD45, determinant 2a. Immunogen Purified L-CA from the Daudi cell line Culture Medium RPMI 1640 + 2mM glutamine + 10%

A cell-permeable, bioactive, non-toxic naphthofurandione analog that blocks STAT3-driven gene transcription. Selectively diminishes gene expression and self-renewal in stemness high cancer cells.

A cell permeable S-adenosyl-L-methionine (SAM) derivative that acts as a highly potent and selective inhibitor of histone 3-lysine79 (H3K79) methyltransferase DOT1L (K i = 500 pM ) and inhibits H3K79 methylation. Does not affect the activity of

Kit for the detection and quantification of apoptotic cell death on a single-cell level by light microscopy in &nbspimmunohistocytochemistry. Contents: Enzyme Solution (TdT) Label Solution (fluorescein-dUTP) Converter AP (anti-fluorescein

Cell Line Origin Mouse P3X63Ag8 x Mouse CAF1 spleen Cell Line Description The antibody is directed against an antigen on human peripheral T cells of the suppresser/cytotoxic subset. Immunogen Human peripheral blood T lymphocytes Culture Medium

Cell Line Origin Mouse NS0/1 x Mouse BALB/c spleen Cell Line Description The antibody is directed against rat CD53 and labels mature T and B cells but only 13% of thymocytes. OX-44 positive cells in the thymus include cells at all stages of