Established Human Mutant Cell Lines

This product is a panel of three (3) genetically modified cell lines involving the NY-ESO-1 gene. The panel consists of a NY-ESO-1 knockout cell line (NY-ESO-1 -/- ) as well as a NY-ESO-1 low and a NY-ESO-1 high expression cell line.

Cell Line Origin Mouse DBA/2 Friend leukaemic lymphoblast Cell Line Description Produced by infecting a DBA/2 mouse with Friend leukaemia virus. Inducible haemoglobin synthesis by exposure to DMSO (reversible action) may represent the

Cell Line Origin Human Caucasian colon adenocarcinoma Cell Line Description Isolated from a primary tumour in a 44 year old Caucasian female. Forms a well-differentiated adenocarcinoma consistent with colony primary, grade I.

Cell Line Origin Human oesophageal squamous cell carcinoma Cell Line Description Established from a poorly differentiated invasive oesophageal squamous cell carcinoma resected from middle intra-thoracic oesophagus of a 77-year-old Japanese man

Cell Line Origin Human oesophageal squamous cell carcinoma Cell Line Description Established from the poorly differentiated invasive oesophageal squamous cell carcinoma resected from the cervical oesophagus of a 51-year old Japanese man prior to

Cell Line Origin Human lymphoblastoid, normal,EBV-transformed Cell Line Description Derived from mononuclear cells from peripheral blood of a 49 year old normal male. Cells were used as controls for cellular radiosensitivity studies and analysis of

Cell Line Origin Human megakaryoblastic leukaemia Cell Line Description Derived from the bone marrow of a 55 year old male with chronic myelogenous leukaemia. All karyotypes show the Philadelphia chromosome.

Cell Line Origin Human Caucasian oesophageal carcinoma Cell Line Description The cell line OE19, also known as JROECL19, was established in 1993 from an adenocarcinoma of gastric cardia/oesophageal gastric junction of a 72 year old male patient.

Cell Line Origin Human Caucasian oesophageal squamous cell carcinoma Cell Line Description OE21, also known as JROECL21, was established in 1993 from a squamous carcinoma of mid oesophagus of a 74 year-old male patient. The tumour was identified as