Cephaeline dihydrochloride (C09-1120-877)

Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC 50 of 121 μM.In VitroCYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: 121 μM (CYP2D6), Ki: 54 μM (CYP2D6). Specification: 0.99 Molecular Formula: C28H40Cl2N2O4 Molecular Weight: 539.53 EC Number: 227-463-3 PubChem CID: 23615629 Isomeric SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)O)OC)OC)OC.Cl.Cl