DASA-58 (C09-0862-012)

InformationDASA-58 DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator.TargetsPKM2In vitroDASA-58 inhibits LPS-induced Hif-1α and IL-1β, as well as the expression of a range of other Hif-1α-dependent genes in primary BMDMs, and also inhibits glycolysis and the accumulation of succinate in LPS-activated macrophages. In PC3 cells, DASA-58 impairs stromal-induced EMT program by restoring PK activity and abrogating the nuclear translocation of PKM2, as well as its association with HIF-1α. DASA-58 also dramatically reduces (~6-fold) CAFs-induced lung metastases formation in PC3 cells.In vivoDASA-58 (40 μM) affects EMT of prostate cancers and tumor dissemination in SCID mice. Specification: 0.98 Molecular Formula: C19H23N3O6S2 Molecular Weight: 453.53 PubChem CID: 44543605 Isomeric SMILES: C1CN(CCN(C1)S(=O)(=O)C2=CC=CC(=C2)N)S(=O)(=O)C3=CC4=C(C=C3)OCCO4 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/D413874-SCI_d51288bbbe0a8381082410ddb82e4f3f.pdf