GSK-3 Inhibitor II is a potent inhibitor of GSK-3β (glycogen synthase kinase-3β) (IC|50|=390 nM). GSK-3 was first discovered to be involved in the control of glycogen metabolism, but has since been indicated in regulating a diverse range of cellular functions, such as neuronal cell survival and death. GSK-3β plays an important role in cardiomyopathies and has been shown to decrease MRP2 expression in neuronal growth factor (NGF)-induced PC-12 cells . Activation of GSK-3β plays a critical role in diabetes-related changes in cardiac energy metabolism, inflammation, nitrosative damage, and remodeling. Specification: ≥95% Molecular Formula: C14H10IN3OS Molecular Weight: 395.22 PubChem CID: 6539732 Isomeric SMILES: C1=CC(=CC(=C1)I)CSC2=NN=C(O2)C3=CC=NC=C3 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G338641-SCI_68a55d5e5924f2d2a0096bb6630a0be7.pdf
- UPC:
- 51112000
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G338641-10mg
- CAS:
- 478482-75-6
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P264
