IM1761092 HYDROCHLORIDE (C005B-308540)

Catalog No.: C005B-308540
Mfr. No.: SML3747-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $1,382.74

List Price: $1,536.38

Biochem/physiol Actions IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μ:M post 6h treatment: HEPG2 C3A cells) and exhibits significantly higher potency

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Description
Specifications

Biochem/physiol Actions

IM1761092 (IM1092) is a biguanide-based mammalian respiratory complex I inhibitor that reduces cellular oxygen consumption (IC50 = 3.6 μM post 6h treatment; HEPG2 C3A cells) and exhibits significantly higher potency than metformin and phenformin (by 10- to 2000-fold depending on the conditions) using bovine heart mitochondrial membrane preparations (IM1092/phenformin/metformin IC50 = 32 μM/3.8 mM/99 mM against active complex I, 4 μM/131 μM/33 mM against deactive complex I).

Caution

Hygroscopic

UPC:: 51162630
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3747-25MG
CAS:: 1820014-33-2

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