Biologically Active Small Molecules

An antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC₅₀ = 100 nM) inhibits ADP-induced platelet aggregation ex vivo shown to be beneficial in the

An antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC₅₀ = 100 nM) inhibits ADP-induced platelet aggregation ex vivo shown to be beneficial in the

An activator of the ATP-sensitive K+ channels that displays anti-ischemic (EC25 = 8.9 &muM) and cardioprotective (IC₅₀ = 0.03 &muM) effects in rat hearts.

An activator of the ATP-sensitive K+ channels that displays anti-ischemic (EC25 = 8.9 &muM) and cardioprotective (IC₅₀ = 0.03 &muM) effects in rat hearts.

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human

Diets high in fiber contain plant lignan species that may be directly responsible for some observed health benefits of these diets. Enterolactone is an enterobacterial breakdown product of plant lignans that is absorbed and can be measured in human

A nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora exhibits EC50 values of 200 and 74 nM for human ER&alpha and ER&beta, respectively and induces breast cancer cell

A nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora exhibits EC50 values of 200 and 74 nM for human ER&alpha and ER&beta, respectively and induces breast cancer cell

A nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora exhibits EC50 values of 200 and 74 nM for human ER&alpha and ER&beta, respectively and induces breast cancer cell

A nonsteroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora exhibits EC50 values of 200 and 74 nM for human ER&alpha and ER&beta, respectively and induces breast cancer cell

An L-type calcium channel blocker that is selective over N-, R-, P/Q- and T-type calcium channels displays antihypertensive activity, lowering arterial blood pressure without altering cardiac contractility.