Biologically Active Small Molecules

An inhibitor of p53-Mdm2 interaction (IC50 = 0.09 &microM) induces the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53.

A carnitine ester that inhibits carnitine-acylcarnitine translocase (IC₅₀ = 33 &muM).

A carnitine ester that inhibits carnitine-acylcarnitine translocase (IC₅₀ = 33 &muM).

A carnitine ester that inhibits carnitine-acylcarnitine translocase (IC₅₀ = 33 &muM).

An endogenous biogenic amine commonly found in invertebrates similar to norepinephrine in structure and action in invertebrates considered a trace amine which may interfere with aminergic pathways in humans.

An endogenous biogenic amine commonly found in invertebrates similar to norepinephrine in structure and action in invertebrates considered a trace amine which may interfere with aminergic pathways in humans.

A metabolite of ethanol produced in the brain that stimulates dopamineric neurons at 0.1 &muM.

A metabolite of ethanol produced in the brain that stimulates dopamineric neurons at 0.1 &muM.

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic &alpha2 receptors (Kis = 1,272, &gt10,000, 955, and 509

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic &alpha2 receptors (Kis = 1,272, &gt10,000, 955, and 509

A selective agonist of the dopamine D1-like receptor (Ki = 1.9 nM) that demonstrates comparatively lower binding affinity for the dopamine D2, dopamine D3, serotonin 5-HT2A, and adrenergic &alpha2 receptors (Kis = 1,272, &gt10,000, 955, and 509

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer.