Biologically Active Small Molecules

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer.

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer.

A mixture of the potent and selective CB1 receptor antagonist SLV 319 (Ki = 7.8 nM) and its distomer, SLV 319 (+)-enantiomer.

A &beta1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein.

A &beta1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein.

A &beta1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity often used to examine the activity of the drug-transporting MDR1 gene product P-glycoprotein.

A flavanonol that suppresses the inflammatory response in mouse models and decreases lipid synthesis in liver cells regulates gene expression through the ARE in HCT 166 cells and inhibits MMPs, most notably MMP-12 (IC₅₀ = 5.7 &microM).

A flavanonol that suppresses the inflammatory response in mouse models and decreases lipid synthesis in liver cells regulates gene expression through the ARE in HCT 166 cells and inhibits MMPs, most notably MMP-12 (IC₅₀ = 5.7 &microM).

A flavanonol that suppresses the inflammatory response in mouse models and decreases lipid synthesis in liver cells regulates gene expression through the ARE in HCT 166 cells and inhibits MMPs, most notably MMP-12 (IC₅₀ = 5.7 &microM).

A flavanonol that suppresses the inflammatory response in mouse models and decreases lipid synthesis in liver cells regulates gene expression through the ARE in HCT 166 cells and inhibits MMPs, most notably MMP-12 (IC₅₀ = 5.7 &microM).

An immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC₅₀ = 8.5 nM), a ubiquitously-expressed E3 ligase, and DDB1 complexes.

An immunomodulatory and antiproliferative compound that interacts directly with the protein CRBN (IC₅₀ = 8.5 nM), a ubiquitously-expressed E3 ligase, and DDB1 complexes.