Biologically Active Small Molecules

A second-generation analog of (R)-roscovitine that inhibits Cdk1, 2, 5, and 9 (IC₅₀s = 0.09, 0.

An ER agonist that binds to ER&alpha and ER&beta with Ki values of 27.4 and 15.4 nM, respectively demonstrates higher ER agonist activity at ER&alpha compared to ER&beta (EC50 = 66 and 330 nM, respectively).

An ER agonist that binds to ER&alpha and ER&beta with Ki values of 27.4 and 15.4 nM, respectively demonstrates higher ER agonist activity at ER&alpha compared to ER&beta (EC50 = 66 and 330 nM, respectively).

An ER agonist that binds to ER&alpha and ER&beta with Ki values of 27.4 and 15.4 nM, respectively demonstrates higher ER agonist activity at ER&alpha compared to ER&beta (EC50 = 66 and 330 nM, respectively).

An ER agonist that binds to ER&alpha and ER&beta with Ki values of 27.4 and 15.4 nM, respectively demonstrates higher ER agonist activity at ER&alpha compared to ER&beta (EC50 = 66 and 330 nM, respectively).

A member of the 2-aryl propionic acid group of NSAIDs that reduces inflammation through inhibition of NF-&kappaB and AP-1 activation decreases survival of prostate tumor cells by inducing p75NTR protein expression inhibits the enzyme

A member of the 2-aryl propionic acid group of NSAIDs that reduces inflammation through inhibition of NF-&kappaB and AP-1 activation decreases survival of prostate tumor cells by inducing p75NTR protein expression inhibits the enzyme

A member of the 2-aryl propionic acid group of NSAIDs that reduces inflammation through inhibition of NF-&kappaB and AP-1 activation decreases survival of prostate tumor cells by inducing p75NTR protein expression inhibits the enzyme

A member of the 2-aryl propionic acid group of NSAIDs that reduces inflammation through inhibition of NF-&kappaB and AP-1 activation decreases survival of prostate tumor cells by inducing p75NTR protein expression inhibits the enzyme

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC₅₀ = 3.3 &microM) demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 &microM).

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC₅₀ = 3.3 &microM) demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 &microM).

A bacterial DNA gyrase inhibitor that disrupts supercoiling activity (IC₅₀ = 3.3 &microM) demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs range from 10-80 &microM).