Ruxolitinib

A ROCK-I inhibitor (IC₅₀ = 25 &microM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay also inhibits ROCK-II and PRK2 with similar potency, while

A ROCK-I inhibitor (IC₅₀ = 25 &microM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay also inhibits ROCK-II and PRK2 with similar potency, while

Application 3-Hexyne was used in the synthesis of fused hetero-hydropyridyl ligands bonded to the {Ru( p -cymene)} organometallic moiety by reacting with ruthenacycles . It was also used in the preparation of [4+2] cycloaddition product by reacting

Application Akt plays a role in signal transduction pathways of cell proliferation, apoptosis, angiogenesis, and diabetes. Akt1 and Akt2 dual kinase inhibitors are capable of sensitizing tumor cells to certain apoptotic stimuli, and inhibit Akt

Application Akt plays a role in signal transduction pathways of cell proliferation, apoptosis, angiogenesis, and diabetes. Akt1 and Akt2 dual kinase inhibitors are capable of sensitizing tumor cells to certain apoptotic stimuli, and inhibit Akt

Biochem/physiol Actions AKT3 or Protein Kinase B g (PKBg) is a serine/threonine kinase that is a member of the AKT family. AKT3 is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components.

General description RAC-alpha serine/threonine-protein kinase (EC 2.7.

Anti-MKLN1 muskelin 1, intracellular mediator containing kel

Immunogen Synthetic peptide directed towards the N terminal region of human PAX7 Biochem/physiol Actions PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain,

Immunogen Synthetic peptide directed towards the middle region of human PAX7 Biochem/physiol Actions PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an

General description Retinoblastoma (Rb) is a pediatric intraocular neoplasm caused due to the biallelic inactivation of the RB1 gene. Retinoblastoma is also known as RB1 (RB transcriptional corepressor 1).

General description The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin