Prostaglandin D₂-d₉ (C09-1015-830)

Prostaglandin D|2|-d|9|contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions and is intended for use as an internal standard for the quantification of PGD|2|by GC- or LC-mass spectrometry. PGD|2|is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.Mastocytosis patients produce excessive amounts of PGD|2|, which causes vasodilation, flushing, hypotension, and syncopal episodes. PGD|2|is produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase and known as β-trace. In the brain, Produces normal physiological sleep and lowering of body temperature. Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD|2|inhibits human ovarian tumor cell proliferation with an IC|50|value of 6.8 µM. Specification: A solution in methyl acetate Molecular Formula: C20H23D9O5 Molecular Weight: 361.52 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/P385708-SCI_8fa5f93a5f1227e1e77b7f31d2acb5b8.pdf