Quinagolide hydrochloride (C09-1166-264)

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamine D2 receptor agonist. Quinagolide hydrochloride is an inhibitor of prolactin. Quinagolide hydrochloride down-regulates AKT levels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research of cancer.In VitroQuinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines. Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs). Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: Eutopic and ectopic E-MSCs Concentration: 100 nM Incubation Time: 24 h Result: Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.In VivoQuinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Wistar-Furth rats bearing SMtTW tumors Dosage: 0.03-0.6 mg/kg Administration: Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month Result: Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.Form:Solid. Molecular Formula: C20H34ClN3O3S Molecular Weight: 432.02 PubChem CID: 3086400 Isomeric SMILES: CCCN1C[C@H](C[C@H]2[C@H]1CC3=C(C2)C(=CC=C3)O)NS(=O)(=O)N(CC)CC.Cl