Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC 50 of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively.Appearance:SolidIC50& Target:PPAR-δ 2 nM (EC 50 )In Vitro:MBX-8025 is an orally active, potent (EC 50 =2 nM), and specific (750-fold and 2500-fold compared with PPARα or PPARγ receptors, respectively) PPARδ agonist being developed as a lipid-altering agent [2]. MCE has not independently confirmed the accuraIn Vivo:In atherogenic diet-fed Wt mice, administration of Seladelpar sodium salt reduces body weight by ~18% (P<0.05). In contrast, Seladelpar sodium salt produces minimal effect on body weight in atherogenic diet-fed foz/foz mice. Seladelpar sodium salt lowersBiological Activity:Seladelpar sodium salt (MBX-8025) is an orally active, potent and specific PPARδ agonist with an EC 50 of 2 nM, showing more than 750-fold and 2500-fold selectivity over the PPARα and PPARγ receptors, respectively. Specification: 0.98 Molecular Formula: C21H22F3NaO5S Molecular Weight: 466.45
- UPC:
- 12352205
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.09 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- S659166-5mg
- Product Size:
- 5mg
