Tyrphostin A1 (C09-1058-619)

Product description：Tyrphostin A1(AG9) inhibits CD40L-stimulated IL-12 production in macrophage cultures and antigen-induced generation of Th1 cells. IC50 value: Target: IL-12 production inhibitor Addition of increasing concentration of A1 resulted in a dose dependent decrease of IL-12 p40, with maximal inhibition (62.5%) occurring at a dose of 10 μM. tyrphostin A1 blocks CD40L-induced translocation of NF-κB to the nucleus, and reduces the activation of IL-12 p40 gene. In vivo therapy with A1 leads to decrease in generation of myelin basic protein (MBP) specific encephalitogenic T cells. In addition, treatment of SJL/J mice with A1 results in attenuation of experimental allergic encephalomyelitis (EAE) . Tyrphostin A1 is a much weaker inhibitor of TK than other tyrphostins (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase), and therefore often used to differentiate TK-mediated effects of tyrphostins from other non-specific effects.Application：Tyrphostin 1 has been used to study its effect on the increase of transgene expression in HeLa and NIH3T3 cells. Specification: 0.98 MDL Number: MFCD00019787 Molecular Formula: C11H8N2O Molecular Weight: 184.2 PubChem CID: 2063 Isomeric SMILES: COC1=CC=C(C=C1)C=C(C#N)C#N Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T162506-SCI_f7d731035ac622fab5d50ceca99085fe.pdf