VEGFR2 Kinase Inhibitor IV is a 3,6-diaryl substituted pyrazolopyrimidine that acts as a potent, ATP-competitive inhibitor of Flk-1 (VEGFR-2/KDR ; IC|50|= 19 nM). The compound displays ~2-fold greater selectivity for VEGFR-2 over PDGFRb (IC|50|= 34 nM) and 10-fold greater selectivity over VEGFR-1 (Flt-1) and VEGFR-3 (Flt-4; IC|50|= 190 nM) tyrosine kinase activity. VEGFR2 Kinase Inhibitor IV does not inhibit FGFR-1 or Src kinase activity (IC|50|> 1.9 μM). The chemical has been shown to inhibit VEGF-stimulated mitogenesis in human umbilical vein endothelial cells (IC|50|= 387 nM). VEGFR2 Kinase Inhibitor IV also inhibits Flt3 phosphorylation in Flt3/Itd-BaF3 cells. Specification: ≥95% Molecular Formula: C17H13N3OS Molecular Weight: 307.37 PubChem CID: 5329468 Isomeric SMILES: COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CSC=C4)N=C2 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/V338295-SCI_2a86bc38854f142d628b9432057ee680.pdf
- UPC:
- 12352204
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V338295-1mg
- CAS:
- 216661-57-3
- Product Size:
- 1mg
- Precautionary Statement Codes:
- P264
