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((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)proline (c15-1312-941)

((1-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YL)METHYL)PROLINE (C15-1312-941)

Catalog No.
C15-1312-941
Manufacturer No.
920703-100MG
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
MG
Price: $747.43
List Price: $830.48

Application ((1-( tert -Butoxycarbonyl)piperidin-4-yl)methyl)proline is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional

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Application

((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)proline is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920533
920649
920665
920673

Other Notes

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Molecular Weight: 312.40. Empirical Formula: C16H28N2O4. form: powder. Quality Level: 100. reaction suitability: reagent type: linker. functional group: Boc, carboxylic acid. storage temp.: 2-8°C. SMILES string: CC(C)(OC(N1CCC(CC1)CN2CCCC2C(O): O): O)C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
51293006
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
920703-100MG


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