General description
2-Hydroxypropyl-β-cyclodextrin is a cyclic oligosaccharide and used as a pharmaceutical excipient to improve the stability and bioavailability of drugs.
(2-Hydroxypropyl)-β-cyclodextrin, a hydroxyalkyl derivative, is mainly used as a formulation vehicle to increase the dissolution of drugs in water for the successful delivery of medicinal agents to biological systems. It is commonly utilized as a substitute for α-, β- and γ-cyclodextrins.
Application
(2-Hydroxypropyl)-β-cyclodextrin may be used:
- As an analytical standard for the determination of the analyte in pharmaceutical formulations as well as nanoparticle formulations by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC), respectively.
- To study the host-guest interaction with organic low molecular mass compounds prior to their quantification using reversed phase HPLC technique.
- As a mobile phase additive for the effective separation of β-carbolines by HPLC.
- In cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) for the determination of sertraline hydrochloride and the synthesis-related products.
- As a chiral selector to resolve pantothenic acid by capillary electrophoresis.
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
- UPC:
- 12352201
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 389145-25G