Application
(±)-Baclofen has been used as γ-aminobutyric acid receptor B GABAB receptor agonist:
- as well as control GABAergic drug to test its protective effects on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic toxicity
- to test its effects on in vivo motor function tests and performance of mutant mice
- to test its excitability effect on dopaminergic (DA) neurons of the ventral tegmental area (VTA)
- to test its effect in reducing dendritic excitability in Purkinje neurons
Biochem/physiol Actions
Baclofen, a γ-aminobutyric acid (GABA) analog, possesses myorelaxant properties Being a γ-aminobutyric acid receptor B (GABAB) agonist, baclofen may be involved in the potentiation of dendritic potassium K+ channels. It may be useful in blocking transient lower esophageal sphincter relaxation (TLESR) in gastroesophageal reflux disease (GERD). Baclofen may also have scope for treating addictive especially, in alcohol use disorder (AUD).
GABAB receptor agonist; skeletal muscle relaxant; antispastic agent.
- UPC:
- 51152017
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B5399-5G
