[D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt (C15-1199-602)

Amino Acid Sequence

Tyr-Ala-Gly-Nme-Phe-Gly-ol

General description

[D-Ala², N-Me-Phe⁴, Gly⁵-ol]-Enkephalin acetate salt or DAMGO is a full agonist of the μ-opioid receptor. μ-opioid receptor is encoded by the OPRM1 gene, which has a predominant expression in reward-processing areas of brain. It acts as a receptor for endogenous opioids such as β-endorphin, encephalin, as well as foreign opioids such as morphine, heroin, and methadone.

Application

[D-Ala², N-Me-Phe⁴, Gly⁵-ol]-Enkephalin acetate salt or DAMGO has been used:

• for use as a positive control in the assay of G-protein activation with μ-opioid receptor, to assay the inhibition of cAMP inhibition by DAMGO
• for the determination of the suppression of contraction by opioid receptors
• to determine whether the peripheral application of DAMGO suppresses the hypertonic saline (HS)-induced masseter nociception in slightly anaesthetized rats

Biochem/physiol Actions

Enkephalin analog that is a selective agonist at μ-opioid receptors.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.