Amino Acid Sequence
His-Trp-Lys-Trp-Phe-Lys-NH2
General description
[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) is a synthetic analog of the orexigenic peptide hormone called ghrelin.
Application
[D-Lys3]-GHRP-6 has been used:
- to study its role in incretin dysfunction and hyperglycemia in cystic fibrosis
- as an antagonist of growth hormone secretagogue receptor (GHS-R)
- as ghrelin receptor antagonist to study the dose-dependent effects of intraduodenal ghrelin on the glucose infusion rate (GIR) during pancreatic-euglycemic clamp procedure (PECs)
[D-Lys3]-GHRP6 has been used-
- to treat bovine somatotropes to determine the release of GH from treated cells and non-treated or control cells
- for intraperitoneal injection to groups of broiler chicken to determine the effect on feed intake, weight gain, and feed conversion ratio
Biochem/physiol Actions
[D-Lys3]-GHRP-6, a selective growth-hormone secretagogue receptor (GHSR) antagonist displays pro-autophagic effects on skeletal muscle. It can be used to study the dependency of GHSR-1a signalling mediated by acylated ghrelin.
[D-Lys3]-GHRP6 (growth hormone releasing peptide 6) induces the secretion of growth hormone (GH). In the membrane of clonal GC somatotropes, this peptide elevates the number of functional voltage-gated Ca2+ and Na+ channels. Chronic treatment with this peptide causes an elevation in Na+ macroscopic current in bovine pituitary somatotropes in culture, which results in an increase in the release of GH.
- UPC:
- 51201805
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G4535-5MG