[D-Pen2,5]-Enkephalin hydrate (C15-1356-819)

Amino Acid Sequence

Tyr-Pen-Gly-Phe-Pen [Disulfide Bridge: 2-5]

General description

[D-Pen^2,5]-Enkephalin hydrate, also called DPDPE, is a peptide and acts as a δ1-opioid receptor agonist. Opioid receptors are divided into three types called, μ, κ and δ, depending upon their ligands. These ligands are peptides and are classified as enkephalins, endorphins and dynorphins.

Application

[D-Pen^2,5]-Enkephalin hydrate (DPDPE) has been used to study the pharmacodynamic and pharmacokinetic capabilities of polyethylene glycol (PEG) conjugate of DPDPE in rodents. It has been used to study the tendency of opiate self-administration in male Long-Evans rats, in ventral tegmental area (VTA).

Biochem/physiol Actions

Antinociceptive activity mediated through the δ₁ receptor while the modulatory activity is mediated through the δ₂ receptor. Tritiated [D-Pen^2,5]-enkephalin is used as a δ₁ ligand.

Other Notes

Lyophilized from 0.1% TFA in H2O