(E/Z)-BCI hydrochloride (C15-1293-872)

Catalog No.: C15-1293-872
Manufacturer No.: B4313-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Price: $1,656.00

List Price: $1,840.00

Application (E/Z)-BCI hydrochloride has been used: to evaluate the role of the Duox-H 2 O 2 -Dusp6 derepression signaling pathway in heart regeneration as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects as a dual

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Description
Specifications

Application

(E/Z)-BCI hydrochloride has been used:

to evaluate the role of the Duox-H₂O₂-Dusp6 derepression signaling pathway in heart regeneration
as an MKP-1 inhibitor to investigate the role of MKP-1 on bexarotent-induced effects
as a dual specificity phosphatase 6 (DUSP6) inhibitor to study its effects on the proliferation of SKOV3 cells

Biochem/physiol Actions

BCI is an allosteric inhibitor of Dusp6 that acts within the phosphatase domain to prevent the catalytic stimulation of phosphatase activity induced by ERK2 substrate binding. BCI also hyperactivates FGF signaling, since Dusp6 functions as a feedback regulator of FGF signaling.

UPC:: 51141598
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: B4313-25MG

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