General description
(−)-Epigallocatechin gallate, is a bioactive component of green tea accounting for 50-80% of the total catechin content.
Application
(−)-Epigallocatechin gallate has been used as:
- a potential neuroprotective agent to test its protective effect against spinal cord injury and blood-spinal cord barrier (BSCB) leakage
- an effective antioxidant against light-induced photoreceptor degeneration in mice retina
- an antioxidant in retinitis pigmentosa (RP) and reduces oxidative damage and changes circadian rhythms in pigmented heterozygous P23H rat
- to test its reversal effect on Diastolic dysfunction in restrictive cardiomyopathy (RCM) mice
- an anti-cancer agent in colorectal cancer in mice
Biochem/physiol Actions
(−)-Epigallocatechin gallate (EGCG) comprises eight -hydroxyl (OH) groups that determine its high antioxidant property. Other than being an efficient free oxygen radical scavenger, it also acts as a good chelating agent and a modulator of important transcription factors, namely nuclear factor-kappa β (NF-kβ). EGEC is proven to be an efficient anti-obesity agent by increasing energy expenditure, fat oxidation, and lowering appetite in humans. EGCG also acts as an anti-inflammatory and neuroprotective agent in the initial stages of ischemia and spinal cord injury. It reduces caveolin-1 expression, maintaining blood-brain barrier integrity and downregulating pro-inflammatory cytokines.
- UPC:
- 12352211
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- E4268-100MG
- CAS:
- 989-51-5
