General description
D2-like dopamine receptor antagonist targeting D2R (pKi =8.0), D3R (pKi = 7.9), and 5-HT1A R (pKi=5.2). Used to explore D2 like receptor mediated effects in neuropathic pain, and in antagonism studies of DA receptors during heroin usage and cocaine. D2 Receptor selectivity in various preps shows IC50 values around 32 nM.
Biochem/physiol Actions
Reversible: yes
Warning
Toxicity: Standard Handling (A)
Other Notes
Dang, Y. H. et al. 2010. Neurosci.169, 1872.
Platt, D. M. et al. 2010. J. Pharmacol. Exp. Ther.332, 985.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51141575
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5058770001