(VAL5)-ANGIOTENSIN II ACETATE HYDRATE (C005B-238880)

Amino Acid Sequence

Asp-Arg-Val-Tyr-Val-His-Pro-Phe

General description

[Val5]-Angiotensin II ([Val5]-ANG II) is an ANG II analog containing valine as the fifth amino acid in place of isoleucine in an ANG II octapeptide.

Application

[Val5]-Angiotensin II acetate salt hydrate has been used to induce:

• renal damage in mice to study the role of human liver-type fatty acid-binding protein (hL-FABP)
• vascular inflammation in mice to study the interaction of cytosolic copper chaperone antioxidant-1 (Atox1) with tumor necrosis factor (TNF)-receptor-associated factor 4 (TRAF4)
• abdominal aortic aneurysm (AAA) in mice to study the role of vascular ATPase copper transporting α (ATP7α)

Biochem/physiol Actions

[Val5]-Angiotensin II acts as an agonist for the angiotensin II type 1 receptor (AT1 receptor).

Molecular Weight: 1032.15 (anhydrous free base basis). Empirical Formula: C₄₉H₆₉N₁₃O₁₂ · xC₂H₄O₂ · yH₂O. Quality Level: 200. Assay: ≥. 95% (HPLC). form: powder. composition: acetate, 1.2-10.4% . storage temp.: −. 20°C. SMILES string: O.CC(O): O.CC(C)[C@H](NC(: O)[C@H](CCCNC(N): N)NC(: O)[C@@H](N)CC(O): O)C(: O)N[C@@H](Cc1ccc(O)cc1)C(: O)N[C@@H](C(C)C)C(: O)N[C@@H](Cc2cnc[nH]2)C(: O)N3CCC[C@H]3C(: O)N[C@@H](Cc4ccccc4)C(O): O. InChI: 1S/C49H69N13O12.C2H4O2.H2O/c1-26(2)39(60-42(67)33(12-8-18-54-49(51)52)56-41(66)32(50)23-38(64)65)45(70)57-34(20-29-14-16-31(63)17-15-29)43(68)61-40(27(3)4)46(71)58-35(22-30-24-53-25-55-30)47(72)62-19-9-13-37(62)44(69)59-36(48(73)74)21-28-10-6-5-7-11-28. 1-2(3)4. /h5-7,10-11,14-17,24-27,32-37,39-40,63H,8-9,12-13,18-23,50H2,1-4H3,(H,53,55)(H,56,66)(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,64,65)(H,73,74)(H4,51,52,54). 1H3,(H,3,4). 1H2/t32-,33-,34-,35-,36-,37-,39-,40-. . /m0../s1. InChI key: INQPQDZJLFYCRH-AXOAQIBVSA-N. Gene Information: human ... AGTR1(185)
mouse ... AGTR1(11607)
rat ... AGTR1(24180). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).