General description
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 = ~ 50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes.
A novel cysteine protease inhibitor that specifically and efficiently inhibits processing of the p-Prl signal peptide (IC50 ~50 nM) without affecting the activities of signal peptidases and other proteases such as lysosomal cathepsins and proteasomes. (Z-LL)2 ketone does not cause any modification of the proteasomal active site even at 100 µM levels; hence it does not block the action of the multicatalytic proteasome complex.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Processing of the p-Prl signal peptide
Product does not compete with ATP.
Reversible: no
Target IC50: ~ 50 nM inhibiting the processing of the p-Prl signal peptide
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
Z-Leu-Leu-NH-CH₂-CO-CH₂-NH-Leu-Leu-Z
Analysis Note
single spot by TLC
Other Notes
Weihofen, A., et al. 2002. Science296, 2215.
Weihofen, A., et al. 2000. J. Biol. Chem. 275, 30951.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 809.00. Empirical Formula: C43H64N6O9. Quality Level: 100. form: lyophilized solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze. color: off-white. solubility: DMSO: 1 . mg/mL. shipped in: ambient. storage temp.: −. 20°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51141586
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 421050-5MG