General description
Phenanthroline is a heterocyclic organic compound, which forms complexes with metal ions. These complexes have wide applications in biochemistry, catalysis and analytical chemistry. It complexes with iron and is exploited as a redox indicator.
Application
1,10-Phenanthroline monohydrate has been used:
- as an inhibitor of metalloproteinase (MMP) in MDA-MB-231 breast cancer cells
- as a negative control in in situ zymography of mice heart samples
- in in vitro resveratrol chelation and reducing activities assays to chelate iron
When complexed with copper, it possesses nuclease activity that has been used to study DNA-protein interactions.
Biochem/physiol Actions
Metalloprotease inhibitor; chelates iron, zinc and other divalent metals. Effective concentration 1-10 mM.
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
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- UPC:
- 12352200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- P9375-25G
- CAS:
- 5144-89-8
