A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.A cell-permeable, specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2 that interacts with a solvent-accessible pocket near the activation loop of JAK2. Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts. Specification: 0.98 Molecular Formula: C6H6Br6 Molecular Weight: 557.54 PubChem CID: 74603 Isomeric SMILES: C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H276112-SCI_abfadba8b9d70a8cbb849cf66534654f.pdf
- UPC:
- 12352101
- Condition:
- New
- Availability:
- 1 day
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H276112-100mg
- CAS:
- 1837-91-8
- Product Size:
- 100mg
- Hazard Statement Codes:
- H302:H319
- Precautionary Statement Codes:
- P264:P270:P280:P330:P301+P312:P305+P351+P338:P501
