1,2-bis(Heptanoylthio)glycerophosphocholine is a synthetic thiol phosphoglyceride lipid derived from D-mannitol which functions as a substrate for PLA|2|(phospholipase A|2|). Hydrolysis of 1,2-bis(Heptanoylthio)glycerophosphocholine by PLA|2|produces free thiols, which may be derivitized with dithionitrobenzoic acid to form the chromophore for a spectrophotometric assay of intracellular and membrane-bound PLA|2|activity. Release of Arachidonic Acid from membrane phospholipids mediated by PLA|2|is thought to regulate eicosanoid production and marked PLA|2|activity is observed in correlation with inflammation states. Inhibitors of PLA|2|activity, presenting potential intervention upon the inflammatory role of PLA|2|, have been identified using this assay design. 1,2-bis(Heptanoylthio)glycerophosphocholine is a substrate of PLA1. Specification: A solution in ethanol,≥95% Molecular Formula: C22H44NO6PS2 Molecular Weight: 513.69 PubChem CID: 57369907 Isomeric SMILES: CCCCCCC(=O)SC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)SC(=O)CCCCCC Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/B335135-SCI_adcaaaa511e1f7cc0b16c5203523efe3.pdf
- UPC:
- 12352204
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B335135-5mg
- CAS:
- 89019-63-6
- Product Size:
- 5mg
- Hazard Statement Codes:
- H225:H350
- Precautionary Statement Codes:
- P201:P210:P202:P233:P240:P242:P243:P281
