1,2-Dioctanoyl-sn-glycerol (C09-1042-587)

1,2-Dioctanoyl-sn-glycerol is a cell-permeable activator of PKC (protein kinase C). Exhibits lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells. (1,2-dioctanoyl-sn-glycerol), also referred as di-C8, is a short-chain[1] cell-permeable diacyl glycerol.In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.Application：to study its stimulatory effect on protein kinase C (PKC) in human cell lines；as a lipid cofactor in PKC activity assay；in vesicular-fusion protein Sec-18 binding studies；Cell permeable lipid shown to mimic the effect of tumor-promoting phorbol diesters on mitogenesis and EGF binding and action in intact cells. Specification: 0.99 MDL Number: MFCD00036835 Molecular Formula: C19H36O5 Molecular Weight: 344.49 PubChem CID: 148879 Isomeric SMILES: CCCCCCCC(=O)OC[C@H](CO)OC(=O)CCCCCCC Beilstein Registry Number: 1714754 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/S397171-SCI_8b8fe60ddd8bb42b41f4cba8411b860a.pdf