General description
1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.
Application
1-Boc-piperazine may be used in:
- preparation of series of (m-phenoxy)phenyl substituted piperazine derivatives
- termination step during synthesis of α,β-poly(2-oxazoline) lipopolymers via living cationic ring opening polymerization
- preparation of monosubstituted piperazines, e.g. in the synthesis of indazole DNA gyrase inhibitors
- UPC:
- 51286300
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 343536-25G