1-Propylphosphonic acid cyclic anhydride, 50+% soln. in ethy (C08-0649-124)

Synonym(s): 1-Propanephosphonic acid cyclic anhydride, T3P CAS Number: 68957-94-8 MDL: MFCD00006583 EINECS: 422-210-5 Formula: C₉H₂₁O₆P₃ Formula Weight: 318.19 Boiling Point: 77° Flash point: -3°(26°F) Density: 1.080 Refractive Index: 1.4190 Sensitivity: Moisture Sensitive Literature References T3P is a registered trademark of Clariant Group. Condensation agent in formation of amide and ester linkages. In peptide synthesis, gives high yields, low racemization, and minimization of side reactions without the need for additives, as well as easily removable (water soluble) by-products: Angew. Chem. Int. Ed. , 19 , 133 (1980). Also reported for formation of a Weinreb amide in high yield from the acid and N,O-dimethylhydroxylamine: Angew. Chem. Int. Ed. , 36 , 1191 (1997). Activating agent for epoxidation of alkenes, giving cis -stereoselectivity in reactions with allylic alcohols: Tetrahedron Lett. , 35 , 8125 (1994). For a brief reviews of the reagent, see: Synlett , 1369 (2000); 1328 (2007). For peptide reagents, see Appendix 6 . GHS Hazard and Precautionary Statements Hazard Statements: H225-H314-H336 Highly flammable liquid and vapour. Causes severe skin burns and eye damage. May cause drowsiness or dizziness. Precautionary Statements: P210-P260-P303+P361+P353-P305+P351+P338-P405-P501A Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations. Other References Beilstein: 5079255 UN#: UN2924 Hazard Class: 3 Packing Group: II Harmonized Tariff Code: 2934.99 TSCA: No