A c-Myc inhibitor that binds to and distorts the bHLH-ZIP domain of c-Myc (Kd = 2.8 µM), thereby inhibiting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity (IC50 = 146 µM); cytotoxic to c-Myc-overexpressing cells lines (IC50s = 15.6 and 13.5 µM for Daudi Burkitt lymphoma cells and HL60 promyelocytic leukemia cells, respectively).
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- UPC:
- 51112015
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 17408-1
- CAS:
- 413611-93-5