A natural alkaloid that blocks potently inhibits MEK-1 (IC50 = 9 nM); also inhibits numerous kinases in vitro, most notably GSK3β, CDK1/cyclin B, CDK5/p25, CK1, and CDK2/cyclin E (IC50s = 10, 22, 28, 35, and 40 nM, respectively), as well as, less potently, ERK1/2, several isoforms of PKC, and NF-κB.
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- UPC:
- 51111756
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 14198-500
- CAS:
- 82005-12-7