PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. .DELTA.12-PGD2 is one of the initial chemical decomposition products of PGD2. .DELTA.12-PGD2 is an intermediate in the pathway leading to .DELTA.12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities. The metabolism of .DELTA.12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.
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- UPC:
- 41116127
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 12650-500
- CAS:
- 64072-89-5
