12(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and is a potent and selective inhibitor of CaMKII (Ca|2+|/calmodulin-dependent protein kinase II) from rat brain cortex. Also inhibits TXA Synthase (thromboxane synthase) and platelet aggregation via activation of GCS (guanylate cyclase). 12(S)-HPETE is an activator of VR1. Specification: 50 μg/ml in ethanol,≥98% Molecular Formula: C20H32O4 Molecular Weight: 336.47 PubChem CID: 5280892 Isomeric SMILES: CCCCC/C=C/C[C@@H](/C=C/C=C/C/C=C/CCCC(=O)O)OO Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H336047-SCI_84352102cbdb47f7f2baa2830eb8eec5.pdf
- UPC:
- 12352211
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H336047-25μg
- CAS:
- 71774-10-2
- Product Size:
- 25μg
- Hazard Statement Codes:
- H225:H350
- Precautionary Statement Codes:
- P201:P210:P202:P233:P240:P242:P243:P281
