12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid

Catalog No.: C15-1247-569
Manufacturer No.: H7768-10UG
Manufacturer Name: Sigma-Aldrich
Quantity: 10
Unit of Measure: UG

Price: $546.86

List Price: $607.62

Biochem/physiol Actions 12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE).

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Biochem/physiol Actions

12(S)-HETE is a bioactive lipid implicated in angiogenesis, growth, and metastasic action in tumor cell lines and in animal models. Arachidonate 12-lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-(HETE). Alteration in 12-LOX expression or activity has been reported in various carcinomas including prostate carcinoma.

Prometastatic metabolite of arachidonic acid via the 12-lipoxygenase pathway that is expressed in many tumor cell lines. It is produced in coronary microvasculature and is a potent inducer of relaxation and hyperpolarization of these microvessels. It activates large-conductance Ca²⁺-activated K⁺ currents in coronary microvascular smooth muscle.

Packaging

Packaged under Argon.

UPC:: 51283943
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: H7768-10UG

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