(±)13-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. Fresh water hydra was shown to metabolize DHA to 13(R)-HDHA, presumably via 11(R)-LO. (±)13-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
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