15-deoxy-.DELTA.12,14-PGD2 is a synthetic analog of PGD2 and a potential precursor to the PPARγ ligand 15-deoxy-.DELTA.12,14-PGJ2. It possesses cytotoxic effects on L1210 mouse leukemia cells in vitro with an IC50 of 0.3 µg/ml. 15-deoxy-.DELTA.12,14-PGD2 is 10-fold more potent than PGD2 in this activity. However, it is a less effective inhibitor of ADP-induced platelet aggregation (IC50 = 320 ng/ml) compared to PGD2 (IC50 = 3 ng/ml).
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- UPC:
- 51111631
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- 12700-500
- CAS:
- 85235-11-6