15-deoxy-Δ12,14-Prostaglandin J2-d4 contains four deuterium atoms at the 3, 3', 4, and 4' positions. Intended for use as an internal standard for the quantification of 15-deoxy-Δ12,14-PGJ2 by GC- or LC-mass spectrometry. A metabolite of PGJ2 and formed from PGD2 the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 of 2 µM in a murine chimera system.1,2 More potent than PGD2, Δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 for induction of adipocyte differentiation in cultured fibroblasts is 7 µM. Specification: A solution in methyl acetate Molecular Formula: C20H24D4O3 Molecular Weight: 320.5 PubChem CID: 16061109 Isomeric SMILES: [2H]C([2H])(CC(=O)O)C([2H])([2H])/C=C/C[C@H]/1C=CC(=O)/C1=C/C=C/CCCCC
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- D386950-25μg
- Product Size:
- 25μg
