15-keto Fluprostenol isopropyl ester (C09-0930-530)

15-keto Fluprostenol isopropyl ester is a metabolite of Travoprost with weak FP receptor binding affinity. Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Fluprostenol isopropyl ester is a potential metabolite of travoprost when administered to intact animals. 15-keto Fluprostenol isopropyl ester is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response. The efficacy of 15-keto travoprost as an ocular hypotensive has not been established. Specification: A solution in methyl acetate Molecular Formula: C26H33F3O6 Molecular Weight: 498.53 PubChem CID: 10207075 Isomeric SMILES: CC(C)OC(=O)CCC/C=C/C[C@H]1[C@H](C[C@H]([C@@H]1/C=C/C(=O)COC2=CC=CC(=C2)C(F)(F)F)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/K347291-SCI_4772d75e9f9a394524bdfe75c7de0098.pdf