15(r)-15-methyl prostaglandin d2-500 ã¦g

15(R)-15-methyl Prostaglandin D2-500 ÃƒÆ’Ã†â¦g

Catalog No.: C003B-375583
Mfr. No.: 12720-500
Mfr. Name: Cayman Chemical Company
Qty/UOM: 1
UOM: EA

Price: $226.45

List Price: $251.61

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Description
Specifications

The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1 and CRTH2/DP2. 15(R)-15-methyl PGD2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 µM.

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UPC:: 51181628
Condition:: New
Availability:: 3 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
WeightUOM:: LB
MPN:: 12720-500
CAS:: 210978-26-0

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