(±)17-HDHA is an autoxidation product of DHA in vitro. It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes. 17(S)-HDHA can be produced by enzymatic oxidation of DHA using soybean LO and is the putative product of mammalian 15-LOs. 17(S)-HDHA is an inhibitor of U-46619-induced rabbit and rat aortic smooth muscle contraction with IC50 values of 4.9 and 7.2 µM, respectively. (±)17-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
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- UPC:
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- Condition:
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- Availability:
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- Weight:
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- WeightUOM:
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