General description
17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid receptor.
Application
17α-Hydroxyprogesterone has been used:
- for titration against ovarian S9 protein in thin-layer chromatography
- as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
- as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)
Biochem/physiol Actions
17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).
- UPC:
- 41141902
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H5752-25G